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Homeobox transcription factors cdx1 and cdx2 (hereafter, cdx1/2) play key roles in determining the identity of intestinal epithelial cells and regulating their stem cell functions. Cdx1 and cdx2 have a major role in intestinal development and have.
Diseases associated with cdx1 include cholestasis, benign recurrent intrahepatic, 2 and bone sarcoma. Cdx1 and cdx2 encode caudal type homeobox transcription factors 1 and 2 (also known as homeobox proteins cdx1 and cdx2). Northern analysis indicated that expression of cdx1 in adults appears to be limited to the intestine and colon, suggesting a possible role in the terminal differentiation of the intestine.
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Among its related pathways are cytoskeleton remodeling regulation of actin.
Their expressions are commonly reduced in colorectal.
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